CAR-T Cell Therapy

CAR-T Cell Therapy

CAR-T Cell Therapy is a groundbreaking treatment in the field of immunotherapy that uses specially modified T cells to target and destroy cancer cells. It represents a significant advancement in the fight against certain types of cancer.

CAR-T Cell Therapy involves extracting a patient’s T cells, genetically engineering them to express a receptor specific to cancer cells, and then infusing these modified cells back into the patient. The re-engineered T cells can recognize and attack cancer cells, providing a personalized and powerful approach to cancer treatment.

Key Components of CAR-T Cell Therapy

T Cell Collection and Modification

The process begins with the collection of T cells from the patient's blood. These cells are then modified in a laboratory to produce chimeric antigen receptors (CARs) on their surface, enabling them to target specific cancer cells.

Patient Preparation

• Conditioning Therapy: Before receiving CAR-T cells, patients undergo a short course of chemotherapy to prepare their body for the infusion, reducing the number of normal T cells to allow the CAR-T cells to thrive.
• Personalized Treatment: CAR-T Cell Therapy is tailored to each patient, ensuring that the engineered T cells are highly specific to the individual's cancer type.

Infusion of CAR-T Cells

Once modified, the CAR-T cells are infused back into the patient’s bloodstream. These cells then seek out and bind to cancer cells, initiating a targeted immune response that destroys the malignant cells.

Monitoring and Management

After the infusion, patients are closely monitored for any side effects, including cytokine release syndrome (CRS) and neurotoxicity. The healthcare team manages these reactions with supportive care and medications to ensure patient safety.

Long-term Follow-up

Long-term follow-up is essential to evaluate the effectiveness of the therapy and monitor for any late-onset side effects. This follow-up includes regular check-ups, imaging, and blood tests to track the patient’s response to treatment.

Why CAR-T Cell Therapy is Revolutionary

• CAR-T Cell Therapy represents a major leap forward in personalized cancer treatment, offering hope to patients with cancers that are resistant to conventional therapies.
• It provides a targeted approach, minimizing damage to healthy cells and reducing the side effects often associated with traditional cancer treatments like chemotherapy and radiation.
• CAR-T cells can remain in the body long after treatment, providing ongoing surveillance against cancer recurrence, which may result in long-term remission or even a cure.